Can graphene quantum dots cause DNA damage in cells?

  title={Can graphene quantum dots cause DNA damage in cells?},
  author={Dan Wang and Lin Zhu and Jian-feng Chen and Liming Dai},
  volume={7 21},
Graphene quantum dots (GQDs) have attracted tremendous attention for biological applications. We report the first study on cytotoxicity and genotoxicity of GQDs to fibroblast cell lines (NIH-3T3 cells). The NIH-3T3 cells treated with GQDs at dosages over 50 μg mL(-1) showed no significant cytotoxicity. However, the GQD-treated NIH-3T3 cells exhibited an increased expression of proteins (p53, Rad 51, and OGG1) related to DNA damage compared with untreated cells, indicating the DNA damage caused… CONTINUE READING
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