Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

@article{Courtine2007CanEI,
  title={Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?},
  author={Gr{\'e}goire Courtine and Mary Bartlett Bunge and James W. Fawcett and Robert G. Grossman and Jon H. Kaas and Roger Lemon and Irin Maier and John Martin and Randolph J. Nudo and Almudena Ram{\'o}n-Cueto and Eric M. Rouiller and Lisa Schnell and Thierry Wannier and Martin E. Schwab and V. Reggie Edgerton},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={561-566}
}
Progress continues in the development of reparative interventions to enhance recovery after experimental spinal cord injury (SCI). Here we discuss to what extent rodent models of SCI have limitations for ensuring the efficacy and safety of treatments for humans, and under what circumstances it would be advantageous or necessary to test treatments in nonhuman primates before clinical trials. We discuss crucial differences in the organization of the motor systems and behaviors among rodents… CONTINUE READING
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N at ur e P ub lis hi ng G ro up ht tp :// w w w .n at ur e

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