Can estrogenic radicals, generated by lactoperoxidase, be involved in the molecular mechanism of breast carcinogenesis?

@article{Ghibaudi2000CanER,
  title={Can estrogenic radicals, generated by lactoperoxidase, be involved in the molecular mechanism of breast carcinogenesis?},
  author={Elena M Ghibaudi and Enzo Laurenti and P Beltramo and Rosa Pia Ferrari},
  journal={Redox report : communications in free radical research},
  year={2000},
  volume={5 4},
  pages={229-35}
}
Mutations of regulatory genes, which perturb the mechanism of cell replication resulting in abnormal cell proliferation, are the main cause of cancer. Many endogenous and exogenous chemicals (including estrogenic hormones) are known to represent a major carcinogenic risk for humans. 2-OH- and 4-OH-derivatives of estrogenic molecules have been shown to form stable adducts with purine DNA bases and act as 'depurinating' agents, thus altering gene transcription (Cavalieri EL, Stack DE, Devanesan… CONTINUE READING

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