Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa?

@article{Wedlake2008CanBM,
  title={Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa?},
  author={Linda Wedlake and Camilla McGough and Claire Hackett and Kay Thomas and Peter Smith Damian Blake and Kevin Harrington and Diana Tait and Vincent Khoo and David Paul Dearnaley and H. Jervoise N. Andreyev},
  journal={Alimentary pharmacology & therapeutics},
  year={2008},
  volume={27 10},
  pages={980-7}
}
BACKGROUND Reliable, non-invasive biological markers of the severity of radiotherapy-induced damage to the gastrointestinal tract are not available. Clinicians continue to use symptom scores as surrogate indicators of toxicity. AIM To determine whether levels of potential biochemical markers of mucosal toxicity change during pelvic radiotherapy. METHODS Fifty-nine patients (30:29 males:females) with mixed pelvic malignancies, receiving 45-70 Gy were recruited. At baseline and weeks 4 or 5… CONTINUE READING

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The Authors

  • 986 L . WEDLAKE
  • Aliment Pharmacol Ther
  • 2008

Gastrointestinal problems following pelvic radiotherapy : the past , the present and the future

  • Andreyev HJN
  • Clin Oncol
  • 2007

Improving the medical management of radiation - induced gastrointestinal symptoms following therapeutic pelvic radiotherapy : a systematic approach

  • Andreyev HJN
  • Lancet Oncol
  • 2007

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