Can bioimpedance determine the volume of distribution of antibiotics in sepsis?

@article{Balk2005CanBD,
  title={Can bioimpedance determine the volume of distribution of antibiotics in sepsis?},
  author={Martin Bal{\'i}k and Josef Sediv{\'y} and Petr Waldauf and Michal Kol{\'a}ř and V Smejkalov{\'a} and Jan Pachl},
  journal={Anaesthesia and intensive care},
  year={2005},
  volume={33 3},
  pages={345-50}
}
The relationship between the volume of distribution, assessed according to the two-compartmental pharmacokinetic model, and extracellular water estimated by bioimpedance was studied in mechanically ventilated patients with sepsis and capillary leak. A prospective observational study was performed in a twenty-bed general intensive care unit in the university hospital. Patients received either vancomycin (n = 16) or netilmicin (n = 12) for more than 48 hours. Those with ascites, pleural effusion… CONTINUE READING