Can autophagy promote longevity?

@article{Madeo2010CanAP,
  title={Can autophagy promote longevity?},
  author={F. Madeo and Nektarios Tavernarakis and G. Kroemer},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={842-846}
}
Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize… Expand
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