Can anxiety damage the brain?
@article{Mah2016CanAD, title={Can anxiety damage the brain?}, author={Linda Mah and Claudia Szabuniewicz and Alexandra J. Fiocco}, journal={Current Opinion in Psychiatry}, year={2016}, volume={29}, pages={56–63} }
Purpose of review Stress exacerbates mental illnesses such as depression but also appears to increase risk of dementia, suggesting a common mechanism for development of stress-induced affective and cognitive impairment. The purpose of this review is to address the question of whether anxiety ‘damages’ the brain, and to identify potential mechanisms for the link between stress and neuropsychiatric illness. Recent findings Anxiety disorders are associated with alterations in fear neurocircuitry…
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References
SHOWING 1-10 OF 150 REFERENCES
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment
- Psychology, BiologyHippocampus
- 2006
The literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment are discussed.
The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
- Biology, PsychologyNeurobiology of Stress
- 2015
Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.
- Psychology, BiologyArchives of general psychiatry
- 2000
This review examines the evidence for hippocampal atrophy in Cushing syndrome, which is characterized by a pathologic oversecretion of glucocorticoids; (2) episodes of repeated and severe major depression; (3) posttraumatic stress disorder and what cellular mechanisms underlie the overall decreases in hippocampal volume.
Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by α1-adrenergic receptors in medial prefrontal cortex
- Psychology, BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2010
Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future
- Psychology, BiologyBiological Psychiatry
- 2006
Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
- Biology, PsychologyReviews in the neurosciences
- 2008
The finding that the hippocampus can recover from dendritic retraction without any noticeable cell loss is of particular interest, and it is proposed that a chronic stress history, which includes repeated elevation of glucocorticoids, may make the hippocampus vulnerable to potential injury.
Psychosocial stress reversibly disrupts prefrontal processing and attentional control
- Psychology, BiologyProceedings of the National Academy of Sciences
- 2009
It is shown that psychosocial stress induces long-lasting but reversible impairments in behavioral and functional magnetic resonance imaging (fMRI) measures of PFC function in humans, and one mechanism by which disrupted plasticity may contribute to cognitive impairments characteristic of stress-related neuropsychiatric conditions in susceptible individuals is suggested.
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
- Psychology, BiologyBiological Psychiatry
- 2009
Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat
- Psychology, BiologyThe Journal of Neuroscience
- 1996
Evidence is provided of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the m-PFC, as well as amygdAlar integration of behavioral and neuroendocrine components of the rat stress response.
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.
- Psychology, BiologyThe American journal of psychiatry
- 2007
A meta-analysis of functional magnetic resonance imaging and positron emission tomography studies of posttraumatic stress disorder, social anxiety disorder, specific phobia, and fear conditioning in healthy individuals provided neuroimaging evidence for common brain mechanisms in anxiety disorders and normal fear.