Can antihypertensive treatment reverse large-artery stiffening?

  title={Can antihypertensive treatment reverse large-artery stiffening?},
  author={Michel E. Safar},
  journal={Current hypertension reports},
  volume={12 1},
In some controlled therapeutic trials for hypertension, a selective reduction of systolic blood pressure has been obtained with long-term treatment. The greatest effects on cardiovascular outcomes stem from a decrease of central blood pressure through a significant reduction of arterial stiffness, wave reflections, or both. Until now, all protocols have used angiotensin II blockade, mainly through angiotensin-converting enzyme inhibition. Cardiovascular outcomes have been significantly improved… CONTINUE READING
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REASON Project Investigators: Selective reduction of cardiac mass and central blood pressure on low-dose combination perindopril/indapamide in hypertensive subjects

  • N De Luca, RG Asmar, GM London
  • J Hypertens
  • 2004
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