Can anti-IgE be used to treat allergy?
@article{Davis2004CanAB, title={Can anti-IgE be used to treat allergy?}, author={Frances M. Davis and Lani A. Gossett and Kristi Pinkston and Ruey S. Liou and L. K. Sun and Y. W. Kim and Nancy T. Chang and T. W. Chang and Kathrin Wagner and J P Bews and Volker Brinkmann and Harry Towbin and Natarajan Subramanian and Christoph H. Heusser}, journal={Springer Seminars in Immunopathology}, year={2004}, volume={15}, pages={51-73} }
Summary and conclusionA summary of the properties of CGP 51901 is shown in Table 3. On the basis of its binding to IgE and IgE-secreting cells and its activity in vitro and in vivo, CGP 51901 is expected to be able to decrease serum IgE by direct clearance of IgE and by reduction of the numbers and productivity of IgE-secreting cells. The end result of reduction of IgE in the circulation and on mast cells is expected to be the attenuation of IgE-mediated reactions and the improvement in allergy…
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