Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics?

@article{Ehlers2019CanAE,
  title={Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics?},
  author={Anna Ehlers and Mark A Blankestijn and Andr{\'e} Knulst and Marco Klinge and Henny G Otten},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2019},
  volume={49 1},
  pages={
          17-26
        }
}
In vitro allergy diagnostics are currently based on the detection of specific IgE binding on intact allergens or a mixture thereof. This approach has drawbacks as it may yield false-negative and/or false-positive results. Thus, we reviewed the impact of known B-cell epitopes of food allergens to predict transience or persistence, tolerance or allergy and the severity of an allergic reaction and to examine new epitope mapping strategies meant to improve serum-based allergy diagnostics. Recent… CONTINUE READING
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