Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.

@article{Massicotte2002CanAP,
  title={Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.},
  author={Fr{\'e}d{\'e}ric Massicotte and Daniel Lajeunesse and Mohamed Benderdour and J. J. Pelletier and George Hilal and Nicholas Duval and Johanne Martel-Pelletier},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 6},
  pages={491-500}
}
OBJECTIVE To determine the capacity of human subchondral osteoarthritic osteoblasts (Ob) to produce interleukin (IL)-1beta, IL-6, transforming growth factor-beta (TGF-beta) and prostaglandin E(2) (PGE(2)), and determine if a relationship exists between IL-1beta, TGF-beta, PGE(2) and IL-6 production. METHODS We measured the abundance of IL-1beta, IL-6, TGF-beta and PGE(2) using very sensitive ELISA in conditioned-media of human primary subchondral Ob from normal individuals and osteoarthritic… CONTINUE READING
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