Can a minimal replicating construct be identified as the embodiment of cancer?

Abstract

Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis involves a loss of key components of the genetic and signalling molecular networks; hence some authors have suggested that this is part… (More)
DOI: 10.1002/bies.201300098

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