Can a generalized kindling seizure induce a reward state?

@article{Paredes2000CanAG,
  title={Can a generalized kindling seizure induce a reward state?},
  author={Ra{\'u}l G Paredes and Gabriella Muzzi and Elizabeth A. Aguirre and Ver{\'o}nica Romero},
  journal={Epilepsy Research},
  year={2000},
  volume={38},
  pages={249-257}
}
The postictal behavioral depression (PBD), characterized by behavioral immobility and unresponsiveness to environmental stimuli, observed after a stage 5 kindling seizure is opioid dependent. Morphine injection prolongs while naloxone and naltrexone (opioid antagonists) reduce or eliminate PBD. Opioids have clear rewarding actions that can be easily detected by place preference conditioning (PPC). In the present study, we evaluated if the opioid release after a stage 5 kindling seizure that… CONTINUE READING
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