Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

@article{Fan2015CanSO,
  title={Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?},
  author={Zhen Fan and Denise H. Harold and Giuseppe Pasqualetti and Julie Williams and David J. Brooks and Paul Edison},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2015},
  volume={56 5},
  pages={707-13}
}
UNLABELLED Neuroinflammation plays a significant role in Alzheimer disease (AD), and translocator protein (TSPO) PET imaging allows us to quantify this process. However, the binding of second-generation TSPO tracers depends on the TSPO genotype coded by the rs6971 single-nucleotide polymorphism, with a 40%-50% increase in BP in high-affinity binders (HABs) compared with mixed-affinity binders (MABs), whereas low-affinity binders (LABs) are unsuitable for evaluation. Hence, several studies are… CONTINUE READING
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