Can MDMA play a role in the treatment of substance abuse?

@article{Jerome2013CanMP,
  title={Can MDMA play a role in the treatment of substance abuse?},
  author={Lisa Jerome and Shira Schuster and Berra Yazar-Klosinski},
  journal={Current drug abuse reviews},
  year={2013},
  volume={6 1},
  pages={
          54-62
        }
}
A wider array of treatments are needed for people with substance abuse disorders. Some psychedelic compounds have been assessed as potential substance abuse treatments with promising results. MDMA may also help treat substance abuse based on shared features with psychedelic compounds and recent reports indicating that MDMAassisted psychotherapy can reduce symptoms of PTSD. Narrative reports and data from early investigations found that some people reduced or eliminated their substance use after… 
Why MDMA therapy for alcohol use disorder? And why now?
  • B. Sessa
  • Psychology, Medicine
    Neuropharmacology
  • 2018
Methylenedioxymethamphetamine (MDMA) in Psychiatry: Pros, Cons, and Suggestions
TLDR
The proposed potential of MDMA as an adjunct to psychotherapy for PTSD is evaluated and suggestions of alternative treatments based on the behavioral pharmacology and toxicology of MDMA and its enantiomers are presented.
Progress and promise for the MDMA drug development program
TLDR
A series of recently completed phase 2 clinical trials of MDMA-assisted psychotherapy for treatment of PTSD show favorable safety outcomes and large effect sizes that warrant expansion into multi-site phase 3 trials, set to commence in 2018.
Legalizing MDMA-Assisted Psychotherapy for the Treatment of Trauma-Related Mental Health Disorders
TLDR
Considering the limitations of existing treatments for trauma-related disorders, MDMA’s pharmacological and psychological effects, and the growing body of methodologically sound research on MDMA-assisted psychotherapy, legalizing this type of therapy could provide much-needed relief to people struggling with the severe, painful, lifelong effects of trauma and related psychological disorders.
(MDMA): current perspectives
TLDR
Even though MDMA is listed as a Schedule I compound by the Drug Enforcement Agency, MDMA-assisted psychotherapy for patients with chronic, treatment-resistant posttraumatic stress disorder is currently under investigation and initial results show efficacy for this treatment approach, although considerably more research must be formed to confirm such efficacy.
MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder: Implications for Social Work Practice and Research
The pervasive impact of trauma across populations and stages of life has made it imperative that the field of social work remain at the forefront of trauma-informed theory, research, and practice.
Why Psychiatry Needs 3,4-Methylenedioxymethamphetamine: A Child Psychiatrist’s Perspective
  • B. Sessa
  • Psychology
    Neurotherapeutics
  • 2017
Since the late 1980s the psychoactive drug 3,4-methylenedioxymethamphetamine (MDMA) has had a well-known history as the recreationally used drug ecstasy. What is less well known by the public is that
Psychedelics as an emerging novel intervention in the treatment of substance use disorder: a review.
TLDR
The aim of this review is to examine the current standing of evidence regarding psychedelic psychopharmacology and to provide an overview of the use and effectiveness of these drugs in the treatment of SUD, alcohol use disorder, and for smoking cessation.
Can 3,4,-methylenedioxymethamphetamine therapy be used to treat alcohol use disorder?
TLDR
MDMA has some unique pharmacological characteristics – particularly its capacity for reducing the fear response and facilitating engagement in therapy around past psychological trauma – that could make it a useful candidate for tackling the core features of alcohol use disorder.
...
1
2
3
4
...

References

SHOWING 1-10 OF 141 REFERENCES
Breaking the loop: Oxytocin as a potential treatment for drug addiction
Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage?
TLDR
Despite large methodological problems the bulk of evidence suggests residual alterations of serotonergic transmission in MDMA users, although at least partial restitution may occur after long-term abstinence, and functional sequelae may persist even after longer periods of abstinence.
Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
TLDR
The results suggest that the memory de.cits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex.
Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA
  • S. Peroutka
  • Biology, Psychology
    Topics in the Neurosciences
  • 1990
TLDR
This study examines the effects of MDMA in brain, structure-Activity Relationships of MDMA and Related Compounds, and Effect of MDMA-like Drugs on CNS Neuropeptide Systems on the basis of published studies and anecdotal evidence.
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
TLDR
MDMA induces oxytocin release in humans, which may be involved in the characteristic prosocial effects of ecstasy, in a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers.
Treatment of alcoholism using psychedelic drugs: a review of the program of research.
  • M. Mangini
  • Psychology
    Journal of psychoactive drugs
  • 1998
TLDR
The history of one branch of psychedelic research, the therapeutic use of LSD in the treatment of alcoholism, and of the events that led to the relabeling of the "hallucinogens" as drugs of abuse are explored.
Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses.
Alcohol and drug addiction are major public health problems, and existing treatments are only moderately effective. Although there has been interest for over half a century in the therapeutic use of
Phenomenology and Sequelae of 3,4-Methylenedioxymethamphetamine Use
TLDR
Subjective experience of the actual MDMA-induced state, as well as both short-term and relatively longer term sequelae, were examined retrospectively and side effects, insight gained, pleasure, and intensity of the MDMA experience were evaluated.
...
1
2
3
4
5
...