Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

@inproceedings{Cunnane2016CanKH,
  title={Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease},
  author={Stephen C. Cunnane and Alexandre Courchesne-Loyer and Camille Vandenberghe and Val{\'e}rie St-Pierre and M{\'e}lanie Fortier and Marie Hennebelle and Etienne Croteau and Christian Bocti and Tamas Z Fulop and Christian-Alexandre Castellano},
  booktitle={Front. Mol. Neurosci.},
  year={2016}
}
We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive scores that are normal for age. (ii) The regional deficit in brain glucose uptake is present in adults <40 years-old who have genetic or lifestyle risk factors for AD but in whom cognitive decline has not… CONTINUE READING