Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?

Abstract

Developed twitch tension and action potentials were recorded in rabbit ventricular muscle in physiological saline at 30 degrees C stimulated at 0.5 Hz. Addition of 5 microM nifedipine to block Ca entry via Ca channels almost abolished twitches (to 2.5 +/- 0.7%, S.E.M., n = 10 of control). This suggests that under normal conditions Ca entry via Na-Ca… (More)

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@article{Bers1988CanCE, title={Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?}, author={Donald M. Bers and Dane Christensen and Thi Xuan Khanh Nguyen}, journal={Journal of molecular and cellular cardiology}, year={1988}, volume={20 5}, pages={405-14} }