Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes.

@article{Mooney2001CampylobacterUE,
  title={Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes.},
  author={Adele Mooney and Marguerite Clyne and Tom Curran and Dan G. Doherty and Barry Kilmartin and Billy Bourke},
  journal={Microbiology},
  year={2001},
  volume={147 Pt 3},
  pages={735-43}
}
Campylobacter upsaliensis is an emerging human enteropathogen. However, little is known about the pathogenesis of C. upsaliensis infection. In this study the authors demonstrate that C. upsaliensis whole-cell preparations and extracts produce a cytolethal distending toxin (CDT)-like effect on HeLa cells characterized by progressive distension and nuclear fragmentation culminating in cell death over 5 d. To further delineate the nature of this toxic effect in relation to CDT from other pathogens… CONTINUE READING