Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior.

@article{Goehler2008CampylobacterJI,
  title={Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior.},
  author={Lisa Elane Goehler and Su Mi Park and Noel Opitz and Mark Lyte and Ronald P Gaykema},
  journal={Brain, behavior, and immunity},
  year={2008},
  volume={22 3},
  pages={354-66}
}
The presence of certain bacteria in the gastrointestinal tract influences behavior and brain function. For example, challenge with live Campylobacter jejuni (C. jejuni), a common food-born pathogen, reduces exploration of open arms of the plus maze, consistent with anxiety-like behavior, and activates brain regions associated with autonomic function, likely via a vagal pathway. As yet, however, little is known regarding the interface of immune sensory signals with brain substrates that mediate… CONTINUE READING

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