Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways.

@article{Zeng2012CamptothecinIA,
  title={Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways.},
  author={Cheng-Wu Zeng and Xing-Ju Zhang and Kang-Yu Lin and Hua Ye and Shu-ying Feng and Hua Zhang and Yue-Qin Chen},
  journal={Molecular pharmacology},
  year={2012},
  volume={81 4},
  pages={578-86}
}
Camptothecin (CPT) is an effective chemotherapeutic agent for treatment of patients with cancer. The mechanisms underlying CPT-mediated responses in cancer cells are not fully understood. MicroRNA (miRNA) play important roles in tumorigenesis and drug sensitivity. However, the interaction between camptothecin and miRNA has not been previously explored. In this study, we verified that miR-125b was down-regulated in CPT-induced apoptosis in cancer cells and that ectopic expression of miR-125b… CONTINUE READING
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