Camptothecin and taxol: historic achievements in natural products research.

  title={Camptothecin and taxol: historic achievements in natural products research.},
  author={Nicholas H Oberlies and David J. Kroll},
  journal={Journal of natural products},
  volume={67 2},
The research team of Dr. Monroe E. Wall and Dr. Mansukh C. Wani of Research Triangle Institute discovered two first-in-class life-saving chemotherapeutic agents. Camptothecin, first isolated and identified from Camptotheca acuminata, was found to kill cancer cells uniquely via topoisomerase I poisoning. Presently, two first-generation analogues of camptothecin are used to treat ovarian, colorectal, and small-cell lung cancers, and several second-generation analogues are in clinical trials… CONTINUE READING
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