Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.

@article{Wall1995CamptothecinAT,
  title={Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.},
  author={Monroe E. Wall and Mansukhlal C Wani},
  journal={Cancer research},
  year={1995},
  volume={55 4},
  pages={753-60}
}
Camptothecin and taxol are secondary metabolites found, respectively, in the wood bark of Camptotheca acuminata, a native of China, and Taxus brevifolia, found in the northwest Pacific coastal region of the United States. The compounds were isolated guided by bioassay on various extracts and chromatographic fractions. Their unique and hitherto unknown structures were elucidated by nuclear magnetic resonance, mass spectrometry, and X-ray analysis. Both compounds have unique mechanisms of… CONTINUE READING
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