Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

@article{Hosseini2017CamptothecinAI,
  title={Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.},
  author={Sabrina Khageh Hosseini and Stefanie Kolterer and Marlene Steiner and Viktoria von Manstein and Katharina Gerlach and J{\'u}lia Coelho Trojan and Oliver B. Waidmann and Stefan Zeuzem and J{\"o}rg O. Schulze and Steffen Hahn and Dieter Steinhilber and Volker Gatterdam and Robert Tamp{\'e} and Ricardo M Biondi and Ewgenij Proschak and Martin Z{\"o}rnig},
  journal={Biochemical pharmacology},
  year={2017},
  volume={146},
  pages={
          53-62
        }
}
The transcriptional regulator FUSE Binding Protein 1 (FUBP1) is overexpressed in more than 80% of all human hepatocellular carcinomas (HCCs) and other solid tumor entities including prostate and colorectal carcinoma. FUBP1 expression is required for HCC tumor cell expansion, and it functions as an important pro-proliferative and anti-apoptotic oncoprotein that binds to the single-stranded DNA sequence FUSE to regulate the transcription of a variety of target genes. In this study, we screened an… CONTINUE READING
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