Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo.

@article{Girola2015CampheneIF,
  title={Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo.},
  author={N. Girola and C. Figueiredo and C. F. Farias and R. Azevedo and A. Ferreira and S. F. Teixeira and Tabata M. Capello and E. G. A. Martins and A. Matsuo and L. Travassos and J. Lago},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={467 4},
  pages={
          928-34
        }
}
Natural monoterpenes were isolated from the essential oil of Piper cernuum Vell. (Piperaceae) leaves. The crude oil and the individual monoterpenes were tested for cytotoxicity in human tumor cell lineages and B16F10-Nex2 murine melanoma cells. In the present work we demonstrate the activity of camphene against different cancer cells, with its mechanism of action being investigated in vitro and in vivo in murine melanoma. Camphene induced apoptosis by the intrinsic pathway in melanoma cells… Expand
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