Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo.

Abstract

Natural monoterpenes were isolated from the essential oil of Piper cernuum Vell. (Piperaceae) leaves. The crude oil and the individual monoterpenes were tested for cytotoxicity in human tumor cell lineages and B16F10-Nex2 murine melanoma cells. In the present work we demonstrate the activity of camphene against different cancer cells, with its mechanism of… (More)
DOI: 10.1016/j.bbrc.2015.10.041

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@article{Girola2015CampheneIF, title={Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo.}, author={N{\'a}talia Girola and Carlos R Figueiredo and Camyla Fernandes Farias and Ricardo Antunes Azevedo and Adilson Kleber Ferreira and Sarah Fernandes Teixeira and Tabata M Capello and Euder Glendes A Martins and A. Matsuo and Luiz R Travassos and Jo{\~a}o H. G. Lago}, journal={Biochemical and biophysical research communications}, year={2015}, volume={467 4}, pages={928-34} }