Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence

@inproceedings{Gubser2007CamelpoxVE,
  title={Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence},
  author={Caroline Gubser and Rory Goodbody and Andrea Ecker and Gareth Brady and Luke A. J. O'Neill and Nathalie Jacobs and Geoffrey L Smith},
  booktitle={The Journal of general virology},
  year={2007}
}
Camelpox virus (CMLV) gene 176R encodes a protein with sequence similarity to murine schlafen (m-slfn) proteins. In vivo, short and long members of the m-slfn family inhibited T-cell development, whereas in vitro, only short m-slfns caused arrest of fibroblast growth. CMLV 176 protein (v-slfn) is most closely related to short m-slfns; however, when expressed stably in mammalian cells, v-slfn did not inhibit cell growth. v-slfn is a predominantly cytoplasmic 57 kDa protein that is expressed… CONTINUE READING

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