Cambridge Laboratory of Molecular Biology

@article{Cleaver2003CambridgeLO,
  title={Cambridge Laboratory of Molecular Biology},
  author={James E. Cleaver},
  journal={Science},
  year={2003},
  volume={300},
  pages={1875 - 1875}
}
5 Citations

A New Insight into Sanger’s Development of Sequencing: From Proteins to DNA, 1943–1977

TLDR
It is claimed that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology, which leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine.

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Structural and biophysical studies reveal how CaMKII kinases, which are important for cellular learning and memory, are switched on by binding of Ca2+/calmodulin.

References

SHOWING 1-9 OF 9 REFERENCES

THE ROLE OF PEROXIDES IN THE INHIBITION OF DNA SYNTHESIS IN CELLS FOLLOWING IRRIDIATION WITH A U.V. MICROBEAM

TLDR
This work has shown that the rate of DNA syntheses in mammalian cells could be reduced when a microbeam of ultraviolet light was directed into the medium surrounding the cells.

THE SYNTHESIS OF DNA, RNA, AND NUCLEAR PROTEIN IN NORMAL AND TUMOR STRAIN CELLS

  • J. Seed
  • Biology
    The Journal of cell biology
  • 1966
TLDR
Results on nuclear metabolism agree with others previously reported in cell strains derived from tumors; they contrast with results from freshly prepared normal cells, where the net syntheses of DNA, nuclear RNA, and protein are closely associated during interphase.

Clinical trial of radiosensitizers, including synkavit and oxygen inhaled at atmospheric pressure.

(1965). Clinical Trial of Radiosensitizers, Including Synkavit and Oxygen Inhaled at Atmospheric Pressure. Acta Radiologica: Therapy, Physics, Biology: Vol. 3, No. 5, pp. 329-341.

THE SYNTHESIS OF DNA, RNA, AND NUCLEAR PROTEIN IN NORMAL AND TUMOR STRAIN CELLS

  • J. Seed
  • Biology
    The Journal of cell biology
  • 1966
TLDR
It was found that the net syntheses of DNA, nuclear RNA, nuclear protein, and cytoplasmic RNA are closely associated during interphase, and an inhibition of the onset of DNA synthesis was found to block the majority of the accumulation of nuclear protein and RNA.

An attempt to develop a radioactive drug.

Microbeam and partial cell irradiation.

Defective Repair Replication of DNA in Xeroderma Pigmentosum

TLDR
Patients with xeroderma pigmentosum develop fatal skin cancers when exposed to sunlight, and so the failure of DNA repair in the skin must be related to carcinogenesis.

The double helix: a personal view

TLDR
Francis Crick reviews the papers published 21 years ago on the structure of DNA and the reaction to them and concludes that the current understanding of DNA is closer than previously thought.

THE SYNTHESIS OF DNA, RNA, AND NUCLEAR PROTEIN IN NORMAL AND TUMOR STRAIN CELLS

  • J. Seed
  • Biology
    The Journal of cell biology
  • 1966
TLDR
It was found that whereas the net syntheses of nuclear RNA and nuclear protein are closely associated during interphase, they are dissociated from DNA replication to a significant extent.