Calvert's formula for dosing carboplatin: overview and concerns of applicability in high-dose setting.

Abstract

The uniqueness of carboplatin as a chemotherapy drug is in the fact that the systemic drug exposure produced by any dose in a patient can be reasonably estimated on the basis of his or her renal function. Calvert’s formula (1) of delivering a calculated dose in terms of target carboplatin area under the time– concentration curve (AUC) and a measured or… (More)

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