Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.

@article{Yabe1997CalumeninAC,
  title={Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.},
  author={Daisuke Yabe and Taro Nakamura and Nobuo Kanazawa and K. Tashiro and T. Honjo},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 29},
  pages={18232-9}
}
We have identified and characterized a cDNA encoding a novel Ca2+-binding protein named calumenin from mouse heart by the signal sequence trap method. The deduced amino acid sequence (315 residues) of calumenin contains an amino-terminal signal sequence and six Ca2+-binding (EF-hand) motifs and shows homology with reticulocalbin, Erc-55, and Cab45. These proteins seem to form a new subset of the EF-hand protein family expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus… CONTINUE READING