Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

  title={Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production},
  author={Alessio Vagnoni and Michael S. Perkinton and Emma H. Gray and Paul T Francis and Wendy Noble and Christopher J Miller},
  booktitle={Human molecular genetics},
Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. Here, we show that siRNA-mediated loss of calsyntenin-1 in cultured neurons alters APP processing to increase production of Aβ. We also show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased Aβ levels. Calsyntenin-1 is a ligand for kinesin-1… CONTINUE READING
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Calsyntenins Table 1. Case data for human post-mortem brain samples Stage Case no. Sex Age (years) Post-mortem delay

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Braak VI A157/00 F • 2009
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