Calstabin deficiency, ryanodine receptors, and sudden cardiac death.

  title={Calstabin deficiency, ryanodine receptors, and sudden cardiac death.},
  author={Stephan E. Lehnart and Xander H T Wehrens and Andrew Robert Marks},
  journal={Biochemical and biophysical research communications},
  volume={322 4},
Altered cardiac ryanodine receptor (RyR2) function has an important role in heart failure and genetic forms of arrhythmias. RyR2 constitutes the major intracellular Ca2+ release channel in the cardiac sarcoplasmic reticulum (SR). The peptidyl-prolyl isomerase calstabin2 (FKBP12.6) is a component of the RyR2 macromolecular signaling complex. Calstabin2 binding to RyR2 is regulated by PKA phosphorylation of Ser2809 in RyR2. PKA phosphorylation of RyR2 decreases the binding affinity for calstabin2… CONTINUE READING
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