Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.

@article{Choi2001CalsenilinIA,
  title={Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.},
  author={Eun Kyoung Choi and Nikhat F Zaidi and Jon S. Miller and Annette C. Crowley and David E. Merriam and Christina Lilliehook and Joseph D. Buxbaum and Wilma Wasco},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={19197-204}
}
Calsenilin is a member of the recoverin family of neuronal calcium-binding proteins that we have previously shown to interact with presenilin 1 (PS1) and presenilin 2 (PS2) holoproteins. The expression of calsenilin can regulate the levels of a proteolytic product of PS2 (Buxbaum, J. D., Choi, E. K., Luo, Y., Lilliehook, C., Crowley, A. C., Merriam, D. E., and Wasco, W. (1998) Nat. Med. 4, 1177-1181) and reverse the presenilin-mediated enhancement of calcium signaling (Leissring, M. A… CONTINUE READING

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Calsenilin Interacts with the FAD-associated

K. Shirotani, K. Takahashi, W. Araki, K. Maruyama, T. Tabira
J. Biol. Chem • 2000

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