Calreticulin promotes tumor lymphocyte infiltration and enhances the antitumor effects of immunotherapy by up-regulating the endothelial expression of adhesion molecules.

@article{Wang2012CalreticulinPT,
  title={Calreticulin promotes tumor lymphocyte infiltration and enhances the antitumor effects of immunotherapy by up-regulating the endothelial expression of adhesion molecules.},
  author={Hao-Tien Wang and Hsin-I Lee and Jih-Huong Guo and Shih-hui Chen and Zhe-Kang Liao and Kai-Wen Huang and Pao-Ling Torng and Lih-Hwa Hwang},
  journal={International journal of cancer},
  year={2012},
  volume={130 12},
  pages={
          2892-902
        }
}
Tumor-induced angiogenesis has been shown to suppress immune responses. One mechanism is to suppress leukocyte-endothelial cell interaction by down-regulating the expression of adhesion molecules, such as intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin on the tumor endothelium, which enables tumor cells to escape immune surveillance. Calreticulin (CRT), a chaperone protein mainly located in the endoplasmic reticulum, has been shown to exert anti… CONTINUE READING

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