Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia

@inproceedings{Chen2017CalreticulinPI,
  title={Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia},
  author={Xiufen Chen and Dominick Fosco and Douglas E. Kline and Justin P. Kline},
  booktitle={Oncoimmunology},
  year={2017}
}
Exposure of cancer cells to particular chemotherapeutic agents or γ-irradiation induces a form of cell death that stimulates an immune response in mice. This "immunogenic cell death" requires calreticulin (CRT) translocation to the plasma membrane, which has been shown to promote cancer cell phagocytosis. However, it remains unclear whether the effect of CRT on cancer cell phagocytosis is alone sufficient to affect tumor immunity. Acute myeloid leukemia (AML) cells expressing cell-surface CRT… CONTINUE READING
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