Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.

  title={Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.},
  author={Sumiko Gamo and Junya Tomida and Katsuyuki Dodo and Dai Keyakidani and Hitoshi Matakatsu and Daisuke Yamamoto and Yoshiharu Tanaka},
  volume={99 4},
BACKGROUND Various species, e.g., Caenorhabditis elegans, Drosophila melanogaster, and mice, have been used to explore the mechanisms of action of general anesthetics in vivo. The authors isolated a Drosophila mutant, ethas311, that was hypersensitive to diethylether and characterized the calreticulin (crc) gene as a candidate of altered anesthetic sensitivity. METHODS Molecular analysis of crc included cloning and sequencing of the cDNA, Northern blotting, and in situ hybridization to… CONTINUE READING