Corpus ID: 21234496

Calreticulin in the heart.

@article{Michalak2004CalreticulinIT,
  title={Calreticulin in the heart.},
  author={Marek Michalak and Lei Guo and Murray A Robertson and Mira Lozak and M. Opas},
  journal={Molecular and cellular biochemistry},
  year={2004},
  volume={263 1-2},
  pages={
          137-42
        }
}
  • Marek Michalak, Lei Guo, +2 authors M. Opas
  • Published in
    Molecular and cellular…
    2004
  • Medicine
  • Calreticulin is a Ca2+ binding/storage chaperone resident protein of the endoplasmic reticulum. This protein plays a key role in the calreticulin/calnexin cycle and the quality control pathways in the endoplasmic reticulum. Calreticulin deficiency is lethal due to impaired cardiac development. However, over-expression of the protein in developing and postnatal heart leads to bradycardia, complete heart block and sudden death. Ultrastructural evidence indicates that the deficiency associated… CONTINUE READING

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