Calreticulin in the heart

  title={Calreticulin in the heart},
  author={Marek Michalak and Lei Guo and Murray N. Robertson and Mira Lozak and M. Opas},
  journal={Molecular and Cellular Biochemistry},
Calreticulin is a Ca2+ binding/storage chaperone resident protein of the endoplasmic reticulum. This protein plays a key role in the calreticulin/calnexin cycle and the quality control pathways in the endoplasmic reticulum. Calreticulin deficiency is lethal due to impaired cardiac development. However, over-expression of the protein in developing and postnatal heart leads to bradycardia, complete heart block and sudden death. Ultrastructural evidence indicates that the deficiency associated… CONTINUE READING