Calreticulin gene exon 9 frameshift mutations in patients with thrombocytosis

Abstract

Somatic frameshift mutations in exon 9 of the calreticulin (CALR) gene were recently identified in patients with BCRABL-negative myeloproliferative neoplasms (MPNs), particularly essential thrombocythemia and myelofibrosis. Calreticulin is a highly conserved endoplasmic reticulum (ER) luminal Ca2þ -binding chaperone protein with a critical role in the… (More)
DOI: 10.1038/leu.2013.382

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@inproceedings{Chi2014CalreticulinGE, title={Calreticulin gene exon 9 frameshift mutations in patients with thrombocytosis}, author={Jianxiang Chi and Katerina A Nicolaou and V Nicolaidou and Laura Koumas and Andrie Mitsidou and Chryso Pierides and M Manoloukos and K Barbouti and Freiderikh Melanthiou and Chrystalla Prokopiou and George S Vassiliou and Paul A Costeas}, booktitle={Leukemia}, year={2014} }