Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides.

@article{Nair1999CalreticulinDI,
  title={Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides.},
  author={Smita K Nair and Pamela A. Wearsch and Daniel A. Mitchell and James J. Wassenberg and Eli Gilboa and Christopher V Nicchitta},
  journal={Journal of immunology},
  year={1999},
  volume={162 11},
  pages={6426-32}
}
Calreticulin is an endoplasmic reticulum (ER) chaperone that displays lectin activity and contributes to the folding pathways for nascent glycoproteins. Calreticulin also participates in the reactions yielding assembly of peptides onto nascent MHC class I molecules. By chemical and immunological criteria, we identify calreticulin as a peptide-binding protein and provide data indicating that calreticulin can elicit CTL responses to components of its bound peptide pool. In an adoptive… CONTINUE READING

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