Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions.

@article{TotaryJain2005CalreticulinDG,
  title={Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions.},
  author={Hana Totary-Jain and Tally Naveh-Many and Yael Riahi and Nurit Kaiser and J{\"u}rgen Eckel and Shlomo Sasson},
  journal={Circulation research},
  year={2005},
  volume={97 10},
  pages={1001-8}
}
Substrate autoregulation of glucose transporter-1 (GLUT-1) mRNA and protein expression provides vascular endothelial and smooth muscle cells a sensitive mechanism to adapt their rate of glucose transport in response to changing glycemic conditions. Hyperglycemia-induced downregulation of glucose transport is particularly important in protecting these cells against an excessive influx of glucose and consequently increased intracellular protein glycation and generation of free radicals; both are… CONTINUE READING