Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans.

@article{Park2001CalreticulinAC,
  title={Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans.},
  author={Bong-Gyun Park and Dong Gun Lee and Jae Ran Yu and Sung Kook Jung and Keum Suk Choi and Jin Il Lee and Yang Suk Kim and Jae Young Kwon and Andrew W Singson and Woo Keun Song and Soo Hyun Eom and Chang Sik Park and Do Han Kim and Jaya Bandyopadhyay and J. Ahnn},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 9},
  pages={
          2835-45
        }
}
Calreticulin (CRT), a Ca(2+)-binding protein known to have many cellular functions, including regulation of Ca(2+) homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here, we report the functional characterization of Caenorhabditis elegans calreticulin (crt-1). A crt-1 null mutant does not result in embryonic lethality but shows temperature-dependent reproduction defects. In C. elegans CRT-1 is expressed in the intestine, pharynx… CONTINUE READING

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