Calreticulin, Ca2+, and calcineurin - signaling from the endoplasmic reticulum.

  title={Calreticulin, Ca2+, and calcineurin - signaling from the endoplasmic reticulum.},
  author={Jody Groenendyk and Jeffrey M Lynch and Marek Michalak},
  journal={Molecules and cells},
  volume={17 3},
Calcium (Ca2+) is a universal signalling molecule involved in many aspects of cellular function. The majority of intracellular Ca2+ is stored in the endoplasmic reticulum and once Ca2+ is released from the endoplasmic reticulum, specific plasma membrane Ca2+ channels are activated, resulting in increased intracellular Ca2+. In the lumen of the endoplasmic reticulum, Ca2+ is buffered by Ca2+ binding chaperones such as calreticulin. Calreticulin-deficiency is lethal in utero due to impaired… CONTINUE READING


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