Calprotectin expression inhibits bacterial binding to mucosal epithelial cells.

  title={Calprotectin expression inhibits bacterial binding to mucosal epithelial cells.},
  author={K Nisapakultorn and Karen F. Ross and Mark C. Herzberg},
  journal={Infection and immunity},
  volume={69 6},
Squamous mucosal epithelial cells constitutively express calprotectin in the cytoplasm. To study how this antimicrobial protein complex confers epithelial resistance to invading bacteria, an epithelial cell line was stably transfected to express the calprotectin complex. Cells expressing calprotectin resist invasion by Listeria monocytogenes and Salmonella enterica serovar Typhimurium. Calprotectin expression was accompanied by altered actin organization, increased alpha3 integrin expression… CONTINUE READING
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