Calprotectin as a Biomarker for Rheumatoid Arthritis: A Systematic Review

  title={Calprotectin as a Biomarker for Rheumatoid Arthritis: A Systematic Review},
  author={Mads Abildtrup and G. Kingsley and D. Scott},
  journal={The Journal of Rheumatology},
  pages={760 - 770}
  • Mads Abildtrup, G. Kingsley, D. Scott
  • Published 2015
  • Medicine
  • The Journal of Rheumatology
  • Objective. Calprotectin (myeloid-related protein 8/14), a heterodimeric complex of calcium-binding proteins, is expressed in granulocytes and monocytes. Calprotectin levels are high in synovial tissue, particularly in activated cells adjacent to the cartilage-pannus junction. This systematic review evaluates the use of calprotectin as an indicator of disease activity, therapeutic response, and prognosis in rheumatoid arthritis (RA). Methods. Medline, Scopus, and the Cochrane Library (1970–2013… CONTINUE READING
    55 Citations

    Figures, Tables, and Topics from this paper

    Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis
    • 14
    • Highly Influenced
    The Role of Calprotectin in Rheumatoid Arthritis
    • 1
    • Highly Influenced
    • PDF
    Systemic calprotectin and chronic inflammatory rheumatic diseases.
    • 7


    Calprotectin in Rheumatoid Arthritis
    • 37
    The major leukocyte protein L1 as an indicator of inflammatory joint disease.
    • 36