Calponin: thin filament-linked regulation of smooth muscle contraction.

  title={Calponin: thin filament-linked regulation of smooth muscle contraction.},
  author={Steven J. Winder and M. P. Walsh},
  journal={Cellular signalling},
  volume={5 6},
Calponin is a basic, approximately 34,000 M(r), smooth muscle-specific protein which is developmentally expressed in up to four isoforms. Calponin binds very strongly to actin in a Ca(2+)-independent manner and is localized to the thin filaments in smooth muscle, where it is present at a stoichiometry of 1 mol calponin/7 mol actin. The interaction of calponin with actin inhibits the actomyosin MgATPase (cross-bridge cycling rate) without affecting myosin phosphorylation. The calponin-actin… CONTINUE READING
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