Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains mediate neurodegeneration in other pathological states and are abnormally activated in ALS, we investigated the possible ameliorative effects of inhibiting calpain over-activation in hSOD1(G93A) transgenic… (More)
DOI: 10.1111/jnc.13536

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