Calpain proteolysis of αII-spectrin in the normal adult human brain

@article{Huh2001CalpainPO,
  title={Calpain proteolysis of $\alpha$II-spectrin in the normal adult human brain},
  author={Gi Yeong Huh and Susan B. Glantz and Soojung Je and Jon S. Morrow and Jung H. Kim},
  journal={Neuroscience Letters},
  year={2001},
  volume={316},
  pages={41-44}
}
The proteolysis of alphaII-spectrin by calpain may be physiologically involved with synaptic remodeling, long-term potentiation, and memory formation. Calpain activation may also mediate neuronal apoptosis, responses to hypoxic insult, and excitotoxic injury. Surprisingly little is known of the activity of these calpain-mediated processes in the adult human brain. Using an antibody that specifically recognizes calpain-cleaved alphaII-spectrin, we have mapped the topographic distribution of the… Expand
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