Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death.

@article{Liu2003CalpainMP,
  title={Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death.},
  author={Xiuli Liu and Rick G Schnellmann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 1},
  pages={63-70}
}
The goal of the present study was to determine the role of calpain in changes in plasma membrane permeability and cytoskeleton-associated paxillin, vinculin, talin, and alpha-actinin levels during acute renal cell death. The mitochondrial inhibitor antimycin A or hypoxia produced graded plasma membrane permeability in renal proximal tubules (RPTs), first allowing propidium iodide (PI, molecular mass 668 Da) influx and then lactate dehydrogenase (LDH, molecular mass 130 kDa) release… CONTINUE READING

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Suspensions of rabbit renal proximal tubules, in Methods in Renal Toxicology (Zalups RK and Lash LH eds) pp 147–162

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  • 1996
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