Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation

@inproceedings{Kwak2012CalpainmediatedVC,
  title={Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation},
  author={Hyeong-il Kwak and Hojin Kang and Jui M. Dave and Edgar Mendoza and Shih-Chi Su and Steve A. Maxwell and Kayla J. Bayless},
  booktitle={Angiogenesis},
  year={2012}
}
Endothelial cells normally line the vasculature and remain quiescent. However, these cells can be rapidly stimulated to undergo morphogenesis and initiate new blood vessel formation given the proper cues. This study reports a new mechanism for initiating angiogenic sprout formation that involves vimentin, the major intermediate filament protein in… CONTINUE READING