Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.

@article{Xu2007CalpainmediatedMT,
  title={Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.},
  author={Wei Xu and Tak Pan Wong and Nad{\`e}ge Ch{\'e}ry and Tara Gaertner and Yu Tian Wang and Michel Baudry},
  journal={Neuron},
  year={2007},
  volume={53 3},
  pages={399-412}
}
Excitotoxicity mediated by glutamate receptors plays crucial roles in ischemia and other neurodegenerative diseases. Whereas overactivation of ionotropic glutamate receptors is neurotoxic, the role of metabotropic glutamate receptors (mGluRs), and especially mGluR1, remains equivocal. Here we report that activation of NMDA receptors results in calpain-mediated truncation of the C-terminal domain of mGluR1alpha at Ser(936). The truncated mGluR1alpha maintains its ability to increase cytosolic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Targeting NMDA receptors in stroke: new hope in neuroprotection

Molecular Brain • 2018
View 4 Excerpts
Highly Influenced

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 4 Excerpts
Highly Influenced

Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 4 Excerpts
Highly Influenced

Calcium signaling then and now, via Stockholm.

Biochemical and biophysical research communications • 2017

Similar Papers

Loading similar papers…